Cisplatin ototoxisch
WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This … WebSep 15, 2024 · Ototoxicity-Ototoxicity has been observed in up to 31% of patients treated with a single dose of cisplatin (cisplatin injection) 50 mg/m 2, and is manifested by …
Cisplatin ototoxisch
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WebJun 21, 2024 · In this trial, the addition of delayed sodium thiosulfate to cisplatin led to a 48% lower risk of hearing loss. Hearing loss of grade 1 or higher occurred in 63% of the children who did not... WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …
WebAssociation of Sodium Thiosulfate With Risk of Ototoxic Effects From Platinum-Based Chemotherapy: A Systematic Review and Meta-analysis Oncology JAMA Network Open JAMA Network This systematic review and meta-analysis investigates 4 studies for the association of sodium thiosulfate with reduced risk of ototoxic effects among patients t WebSep 20, 2024 · The most common adverse reactions in the two trials (≥25% with difference between arms of >5% compared to cisplatin alone) were vomiting, nausea, decreased …
WebCisplatin-induced ototoxicity results in significant, permanent hearing loss in pediatric and adult cancer survivors. Elucidating the mechanisms underlying cisplatin-induced hearing loss as well as the development of therapies to reduce and/or reverse cisplatin ototoxicity have been impeded by suboptimal animal models. WebApr 26, 2024 · Cisplatin is a highly effective antineoplastic agent used to treat solid tumors. Unfortunately, the administration of this drug leads to significant side effects, including …
WebMay 19, 2016 · He is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease …
WebJul 9, 2024 · cisplatin exposure are the primary reasons that cause ototoxicity by creating serious damage in hair cell membranes [2]. The anti-in ammatory, anti-allergic, anti-viral, and anti-carcinogenic... cincinnati humane society adoptionWebMay 11, 2012 · Cisplatin is a prescription medicine used alone to treat bladder and ovarian cancer.It is also used together with other drugs to help treat testicular cancer, locally … cincinnati hunger walk 2022WebSerum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen Poynter, Michelle Roesler & Jeannette Sample ... We will measure the association between blood serum platinum levels and ototoxicity, while adjusting for age at treatment, time since diagnosis, tumor ... cincinnati human resources information systemWebJun 21, 2024 · This trial compared cisplatin with cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence and severity of cisplatin-related ototoxic effects without jeopardizing overall and event-free survival. Methods: cincinnati hub oh from eureka springs arWebAug 11, 2024 · The FDA has issued a complete response letter to Fennec Pharmaceuticals regarding its new drug application for a unique formulation of sodium thiosulfate (Pedmark) for the prevention of... cincinnati humidity todayWebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 … cincinnati hughes high schoolWebOtotoxicity was more severe with higher cumulative doses and higher individual doses, and was most marked in those patients receiving bolus injections. Loss of perception of higher frequencies was most common. Symptoms of ototoxicity occurred in 23 patients and included deafness, tinnitus, otalgia, and recruitment. dhs milton freewater