Ctcf isoform

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August undefined, 2024

WebNov 30, 2010 · CTCF paralog; CTCF-like protein; Cancer/testis antigen 27 (CT27) Zinc finger protein CTCF-T; Gene names. Name. CTCFL. Synonyms. BORIS. Organism names. Organism. ... Computationally mapped potential isoform sequences. There are 4 potential isoforms mapped to this entry. BLAST Align Add View all. Entry Entry name Gene name … WebAug 1, 2003 · The major isoform of CTCF has a molecular mass of 82 kDa [8]. However due to amino acid sequences in the N- and C-termini, CTCF migrates aberrantly in SDS–PAGE gels [8]. Full-length CTCF migrates at approximately 130 kDa, although several reports in the literature observe a band of approximately 140 kDa [5], [8], [9].

CTCF - Wikipedia

WebFeb 28, 2005 · A control pSG5 plasmid that does not express CTCF was also exploited to establish the basal focus-forming potential of cells in the absence of any exogenous CTCF isoform. Twenty-four hours post-transfection, cells were subjected to G418 selection and two weeks later the number of colonies was counted. WebSep 1, 2024 · The CCCTC-binding factor (CTCF) protein and its modified forms regulate gene expression and genome organization. However, information on CTCF acetylation and its biological function is still... r a whitlow painting and floor sanding inc

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WebJun 23, 2024 · CTCF - an acronym for “CCCTC-binding factor” identified by Lobanenkov et. al. (Eur. J. Biochem. 1986) - is a highly conserved and ubiquitous protein with multivalent 11 Zn Fingers responsible for... WebJun 19, 2014 · It is closer to that of the ENSEMBL ENST00000369429 isoform than to the RefSeq isoform and ~1.6 kb from the 5' end of the RefSeq isoform (Figure 3a). Moreover, the position of the active promoter-type chromatin seen specifically in Mb ( Figure 4 b), which overlaps a constitutively unmethylated DNA region, is consistent with the use of … WebAug 2, 2024 · CTCF is developmentally regulated, and interaction between the CTCF and these lineage-specific protein partners confers various functions during cell development and differentiation, ranging from embryonic stem cells (ESCs) to immune and muscle cells. simple fish batter for frying

An alternative CTCF isoform antagonizes canonical CTCF …

CTCF - an overview ScienceDirect Topics

WebNational Center for Biotechnology Information WebApr 12, 2024 · Putative motifs of CTCF’s zinc fingers identified by interpreting wild-type versus mutant differential peak prediction models. To identify motifs related to the binding of each ZF in CTCF, we trained and interpreted a neural network for predicting whether a peak would be significantly weaker according to DESeq2 [] in the mutant dataset than in the … raw hm1000x reviewWebDec 20, 2024 · Moreover, CTCF interaction with the PARP-1 protein stimulates its enzymatic activity independently of DNA damage [42,45]. ... (ATM) kinase. The H1.2 isoform protects chromatin from aberrant ATM loading and activation in basal conditions. Upon DNA damage, PARP-1 covalently modifies H1.2 at the S188 residue, ... simple fish breading

"WebMar 11, 2014 · CCCTC-binding factor (CTCF) is a DNA-binding protein that has various, often seemingly contradictory, roles in gene regulation. This Review describes these disparate functions and how the context ... " - Ctcf isoform

Ctcf isoform

WebNov 3, 2011 · To dissect the impact of CTCF on exon 5 splicing in a cell-based system, we screened several human Burkitt lymphoma B cell lines for differences in expression of the exon 5 containing CD45RB isoform.

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WebMar 11, 2014 · CCCTC-binding factor (CTCF) is a DNA-binding protein that has various, often seemingly contradictory, roles in gene regulation. This Review describes these … WebSequence & Isoform; Similar Proteins; P49711 · CTCF_HUMAN. Protein. Transcriptional repressor CTCF. Gene. CTCF. Status. UniProtKB reviewed (Swiss-Prot) Organism. …

WebThe statistical significance for the boxplots in (c, d) was assessed by Wilcoxon rank sum test from publication: An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes ... WebApr 1, 2024 · CTCF genomic sites containing the CTCF short isoform fail to stop cohesin extrusion, leading to genome-wide decrease in cohesin occupancy [ 49, 50]. It is unclear whether differential expression of the CTCF short isoform during development or in response to stimuli represents a strategy used by cells to regulate CTCF function.

WebThe short isoform CCAT1-S is also referred as CCAT 1 or cancer-associated region long noncoding RNA-5 (CARLo-5), it is named as CCAT1-S after the long isoform CCAT1-L is discovered . ... (CTCF), regulating the intra-chromosomal interaction of well-studied oncoproteins c-MYC causing CRC tumorigenesis. WebAlthough the open reading frame of the major isoform of CTCF would only encode an 82 kDa protein, CTCF migrates at a much higher molecular weight ( 130 kDa) (41). In our studies, we observed the ...

WebImportantly, the methylation level at CpG sites nearest to the CTCF binding and first exon splice-in (ψ) of PPP1R14A were significantly associated with aggressive phenotype in the TCGA PrCa cohort. Meanwhile, the long isoform …

WebApr 14, 2024 · Numerous studies have shown that CTCF regulates enhancer–promoter interactions and the human genome contains thousands of CTCF binding sites ... Variation in eNEMAL level leads to minor changes in MALAT1 expression, but a significantly higher abundance of the long isoform of NEAT1-lncRNA (NEAT1_2) is seen when eNEMAL is … raw hiveWebTopologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. ... article] [Google Scholar] 12. Revenkova E, Eijpe M, Heyting C, Gross B, Jessberger R. Novel meiosis-specific isoform of mammalian SMC1. Mol Cell Biol 2001; 21: 6984–6998. [PMC free article] [Google … ra whitlowWebApr 4, 2024 · CTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order chromatin architecture of … raw holisWebMar 3, 2024 · ChIP-seq identifies sites of BRD8 and CTCF occupancy genome-wide. A, B, The top 7 enriched motifs under BRD8 (A) or CTCF (B) ChIP-seq peaks in Calu-3 cells. Motifs are ranked by their % incidence in target and background regions. ... (Isoform-1, −2, −4 to −7)(Jiang et al., 2016), our RNA-seq analysis identified Isoform-1 and −4 ... raw holdingsWebApr 4, 2024 · Identification of an alternatively spliced CTCF-s isoform in the human genome. a Schematic representation of exons of the human … raw hollow gameWeba short CTCF isoform lacking the N-terminus and 2.5 zinc ngers of CTCF which is encoded by an alterna-tively spliced transcript skipping exons 3 and 4 (Li et al. 2024). CTCF genomic sites bound by the CTCF short isoform might fail to stop cohesin-mediated loop extru - sion in the genome. ese observations suggest that Open Access raw hollandWebAug 1, 2003 · The 155-kDa isoform of CTCF was sensitive to proteolysis during the DNase I digestion at room temperature. Immunoblot analyses of CTCF in nuclei before and after … raw home