WebWe now provide evidence that FkbO and RapK are actually chorismate hydrolases, yielding DCDC (Fig. 2). We have also found that other previously obscure FkbO- and … WebMar 11, 2014 · A novel xanthomonadin-dialkylresorcinol hybrid named arcuflavin was identified in Azoarcus sp. BH72 by a combination of feeding experiments, HPLC-MS and MALDI-MS and gene clusters encoding the biosynthesis of this non-isoprenoid aryl-polyene containing pigment are reported. A chorismate-utilizing enzyme from the XanB2-type …

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin ...

WebDec 10, 2014 · FkbO has a strict preference for chorismate – isochorismate is not accepted as a substrate – therefore the enzyme can be used to selectively hydrolyse … WebDec 10, 2014 · FkbO has a strict preference for chorismate – isochorismate is not accepted as a substrate – therefore the enzyme can be used to selectively hydrolyse chorismate, leading to the chiral building block 3,4-dihydroxycyclohexa-1,5-dienecarboxylate. This simplifies the final purification step, as isochorismate is much easier to separate from the ... income based home rentals

CDD Conserved Protein Domain Family: chori_FkbO_Hyg5

WebOct 9, 2013 · The YjgF-like domain has recently been found in the chorismate-utilizing proteins Hyg5, RapK and FkbO from Streptomyces (Fig. 6A). Hyg5 has recently been shown to catalyse the conversion of chorismate into 3-HBA, while FkbO hydrolyses chorismate to form (4R,5R)-4, 5-dihydroxycyclohexa-1,5-dienecarboxylic acid (Andexer … WebMar 1, 2013 · Figure 2. Chorismate analogues as competitive inhibitors for chorismate-utilising enzymes. The compounds are ordered corresponding to their structural … WebSep 13, 2013 · Europe PMC is an archive of life sciences journal literature. incentive programs for recruiters