Phenylsulfonyl furoxan
WebMay 15, 2024 · In the present study, thirty β-carboline- (phenylsulfonyl)furoxan hybrids (11a-j, 12a-j and 13a-j) were designed and synthesized through esterification and amidation … Web4-Methyl-3-(phenylsulfonyl)furoxan C9H8N2O4S CID 193841 - structure, chemical names, physical and chemical properties, classification, patents, literature ...
Phenylsulfonyl furoxan
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WebNov 10, 2016 · Among the furoxan intermediates, only compounds from the phenylsulfonyl (13a-c) series were active against MTB; the MIC 90 for these compounds ranged from 2.89 to 26.01 μM, while the methyl ( 3a-c) and phenyl ( 7a-c) series presented MIC 90 values superior to 88 μM. WebMay 15, 2024 · Collectively, the novel β-carboline-(phenylsulfonyl)furoxan hybrid 13h possessed prominent antineoplastic activity and sustained NO release capacity in vitro. …
WebAug 10, 2016 · It is found that PSMC2 was upregulated in ovarian cancer tissues, associated with tumor grade and could probably predict poor prognosis and may promote the development of ovarian cancer through CCND1, which may predictpoor prognosis of ovariancancer patients. 2 PDF WebM.S. Bornman, N.H. Aneck-Hahn, in Advances in Pharmacology, 2024 1.3 Fetal exposure. Understanding the critical role of steroid hormones and other stressors in the …
WebJun 23, 2024 · solubility of seco-coumarin and furoxan hybrid 3 with hydrazide side chain was 8.2 μ g/mL in 820-fold higher than 0.01 μ g/mL of the lead 2 , which suggested that hydrazine is a favorable group WebJul 10, 2024 · Furoxan, 1,2,5-oxadiazole N -oxide, is an important scaffold of many compounds that show typical NO-donor properties in mammals, some furoxan derivatives being known as NO-donating pro-drugs [ 23 – 27 ].
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WebApr 29, 2015 · A series of novel hybrids 10a–m were designed and synthesized by coupling phenylsulfonyl furoxans with gemcitabine through various diols or alcohol amine linkers, ... Therefore, our novel findings provide a proof of principle in the design of new furoxan/ gemcitabine hybrids for the intervention of human cancers. About. Cited by. Related ... dps move.mil not working at homeWebA series of novel conjugates of podophyllotoxin and norcantharidin was designed using association strategy, and synthesized by coupling 4 ′-demethylepipodophyllotoxin with N-amino acid norcantharimides, and their cytotoxicitiy was evaluated against four human tumor cell lines (A-549, HepG2, HeLa and HCT-8) and normal human diploid fibroblast line … emilee chapman stanfordWebNanoparticles obtained from the coassembly of either 4-(1-(3-methylpentan-5-ol)oxyl)(3-phenylsulfonyl) furoxan (compound 1) or 4-methoxy(3-phenylsulfonyl) furoxan (compound 2) with Pluronic F127 exhibit 4-fold improved antimicrobial activities compared to their self-assembled counterparts without Pluronic F127. 5(6)-Carboxylfluorescein (CF ... emilee cohenWebTo develop multifunctional drugs, a series of celastrol/NO donor hybrids were designed, synthesized and evaluated. The detection of NO release amounts showed that the more NO of these hybrids released, the more tumor cells were inhibited. 11b, which released the highest level of NO in vitro, exhibited superior potency (IC 50 = 0.48 ± 0.06 μM) compared … dps.move.mil helpWebFeb 5, 2024 · In order to find new anticancer drugs, a series of novel furoxan-based coumarin derivatives (10a–k) were synthesized and evaluated for their antiprol Design, … dps move privacy errorWebNov 10, 2014 · The NO-releasing capacity and the inhibition of ERK/MAPK pathway signaling may explain the potent antineoplastic activity of these compounds. Sixteen furoxan-based nitric oxide (NO) releasing coumarin derivatives (6a-c, 8a-g, 10a, 13a,b, 15, and 17a,b) were designed, synthesized, and evaluated against the A549, HeLa, A2780, A2780/CDDP, and … dps moves armyWebA New Furoxan NO-Donor Rabeprazole Derivative and Related Compounds emilee cork